Based on Capcom's award-winning Onimusha franchise, the manga is the prequel to the Shin Onimusha: Dawn of Dreams video game that features tales from feudal Japan. Yuki continues his quest to destroy the tainted cherry trees and thwart Hideyoshi's diabolic ambitions, while Akane departs on her quest for vengeance against Munenori, traitor to the Yagyu Clan. The fiery intensity that is the world of Onimusha continues!

Shin Onimusha: Night Of Genesis was published in English as Onimusha: Night Of Genesis by Udon Entertainment on June 6, 2006 and January 30, 2007, respectively.