On the moon, there is an old shrine that has fallen into ruin. On the birthday of Himeko Kurusugawa and Chikane Himemiya, there is a sudden eclipse, and a voice calls the eight necks of Orochi to rise and destroy the Solar Priestess and the Lunar Priestess. The two girls soon find themselves under attack by the Orochi, but Himeko's close friend Souma has resisted the call of the Orochi and has sworn to protect her, no matter what.

Kannazuki no Miko was published digitally in English by VIZ Media under the VIZ Select imprint from January 26, 2016 to February 23, 2016. The series was previously published by TokyoPop as Destiny of Shrine Maiden on May 6 and July 7, 2008 respectively.