The main character is a detective, Kazuhiko Amamiya, suffering from multiple personality disorder. Starting out as a violent detective series with a twist (the twist being the variant personalities that take over Detective Amamiya at various intervals), the series evolves into an exceptionally complex and involved sci-fi conspiracy story.

Tajuu Jinkaku Tantei Psycho has been published as MPD Psycho in English by Dark Horse Comics since June 12, 2007. It has also been released in German by Carlsen Verlag under its Hayabusa label since September 17, 2022.