The stage is a small clinic in the suburbs, in a world in which humans with cat and dog ears are commonplace. Jack, the protagonist and a dog-man, works as the assistant for Dr. Crane, the head doctor of a secluded animal clinic where various cat-girls are being treated. Jack has no memory of his life before coming to the clinic, and he works for Dr. Crane to repay her kindness after she took him in. However, as the only male in the clinic, a certain serious role was imposed: Jack is to have sexual intercourse with the patients to cure their regular symptoms caused by an illness called "DOTES."