The story follows young Makishima Misaki as she returns to her Grandfather's old house following his death. She is accompanied by her father, Kyoichi, an awkward widower. Once there she finds that since she is the only blood relation to her grandfather, she is the sole owner of her grandfather's house and artifacts. Barely remembering the house she visited as a toddler, Misaki is understandably reluctant to leave her school and friends behind. However, she soon makes new friends, including one that is beyond her imagination!

Chikyuu Misaki was published in English as Chikyu Misaki by CMX Manga from September 1, 2005 to March 9, 2006.