The manga begins in 2004 with the late Apple company co-founder Steve Jobs traveling to Colorado to surprise author Walter Isaacson with a request: to pen his life story. Isaacson muses if Jobs is comparing himself with Benjamin Franklin and Albert Einstein, the subjects of two Isaacson biographies. The author puts off writing Jobs' story until he receives a call from Jobs' wife Laurene with shocking news: Jobs has cancer.

Steve Jobs is an adaptation of Walter Isaacson's biography of the late Apple company co-founder Steve Jobs.