The series takes place during Sachiko Shinozaki's birthday and she wants to play a game with the unfortunate students who wounded up in Heavenly Host Elementary School. The characters are forced to participate in a variety of games and do whatever it takes to entertain her.

Corpse Party: Sachiko no Renai Yuugi♥ - Hysteric Birthday 2U is based on the 2012 PSP video game of the same name