Akira, a second year middle school student, has a normal life on an island of solitude, a serene and peaceful school setting. Akira's daily life is shattered one day by the transfer of a mysterious boy; Matsushiro Nishigami who introduces himself as a shinigami with the phrase "Anyone who gets close to me dies." What could be the meaning of such a bizarre introduction?

Due to the author Himura Masaki's illness, Shindere Shoujo to Kodoku na Shinigami was put on an indefinite hiatus after its 20th chapter was published on March 28, 2013. Himura passed away on June 17, 2015 after more than two years of fighting cancer, leaving this and another series she started while being in the hospital—Nyuuin Note (Hospitalization Notebook)—in an unfinished state. The last volume containing chapters 15 to 20 was published only in digital format on September 24.