Welcome to the Zarlburg Royal Magic Academy—producers of the best alchemists in the world! When Marie, Zalburg's prodigal daughter and premier alchemist, returns to her alma mater after thrilling journeys in many foreign lands, she suddenly realizes things are not too exciting at home. But all that changes after running into fellow alchemist Elie, who has plans to open an alchemy workshop and become famous. Now, adventure comes to them in all shapes and sizes—curious elves, flying broomsticks, giant monsters, and explosive bombs.

Marie to Elie no Atelier: Zarlburg no Renkinjutsushi was partially published in English by Tokyopop, who published the first four volumes from August 7, 2007 to July 8, 2008, under the title Atelier Marie and Elie: Zarlburg Alchemist, before dropping the license and becoming defunct.