Yuta Miyagi, an orphan, is stunned when three beautiful strangers, who reveals to be his half-sisters, to occupy the house organizing their activities of "paranormal investigator". The approach to the paranormal is partly scientific. The three will use their knowledge of science and mysticism in order to control ghosts, attendance and more without using always strange technical or magical qualities / mediumship.

Shinrei Chousa Shitsu: Office Rei was originally serialized in Weekly Shounen Magazine until April 3, 1996 (1996 #18). It was then moved to Magazine Special on May 20 (1996 No.6).