Makoto Hanaoka, a womanly second-year student, easily attracts other people's attention. First-year student Saki Aoi is no exception, and she falls in love with Makoto at first sight. Having a vibrant and vigorous personality, she does not hesitate to confess her feelings to her senior. However, Makoto differs significantly from the person Saki perceives: Makoto is not a girl, but rather a cross-dressing boy! After revealing his well-known secret to Saki, Makoto expects her to be disgusted. Surprisingly, she is instead captivated by this revelation. Nonetheless, he still rejects her, but Saki's determination does not stop her from declaring that she will become his first love. With Saki and his childhood friend at his side, Makoto's world brightens, giving him strength amid his struggle between his interests and the expectations placed on him. [Written by MAL Rewrite]

Senpai wa Otokonoko is based on the web manga Otokonoko ga Kouhai ni Kokuhaku sareru Hanashi (おとこのこが後輩に告白される話), released on the author's Twitter and pixiv accounts from July 3, 2019, to July 24, 2019. The series was published digitally in English as Senpai Is an Otokonoko by Webtoon Entertainment from March 9, 2023, to February 8, 2024. Webtoon Entertainment also released the series in French from March 28, 2022, to February 5, 2024; and in German since May 28, 2022. The volumes have been published in English as Senpai Is an Otokonoko: My Crossdressing Classmate by Kodansha USA since June 17, 2025.