Wanting a job near his university, 18-year-old Renji Kusakabe works as a clerk at an arcade. During his shift on Valentine's Day, he notices a British girl, Lily Baker, struggling to win a stuffed animal from a claw machine. After watching her lose for hours, Renji decides to jump in and win the prize with his impressive gaming skills. As he gives the toy to her as a gift for the special day, Lily mistakes the deed as a confession of love. Even though Lily seems wary of Renji at first, she soon takes an interest in him. Not long after, they begin a cultural exchange, teaching each other their languages and traditions. As their paths continue to cross at the arcade, the two are bound to have vibrant times ahead. [Written by MAL Rewrite]

Game Center Shoujo to Ibunka Kouryuu began as a one-shot published in Jump GIGA Winter 2019 vol.3 under the title "Game Center Ibunka Kouryuu" (ゲーセン異文化交流). Official serialization began on Dra-Dra Sharp# on May 15, 2020.