Set in the near future in Japan, year 2035. A major incident was known as "Burst" which was caused by researching artificial life. A certain AI called "Matter" has eroded the Kurobe Gorge. Entering the research city, which has been called as humanity's last hope, has been prohibited by the government. Two years later, Aiko Tachibana, a 15-year-old girl who lost her family from the incident, was told by a transfer student, Yuuya Kanzaki, the truth that Aiko didn't know regarding a secret hidden within her body. The key to solve the mystery is said to be in the Primary Point, the center of Burst. When a boy and a girl, who bears the future of humanity, meet, what will be the new truth? (Source: MAL News)

A.I.C.O.: Incarnation was published digitally in English by Kodansha Comics USA from April 10, 2018 to December 10, 2019.