Clotho Buer, along with Orga Sabnak and Shani Andras are part of the Earth Forces Federation. They are classified as "biological CPU's" assigned to the new Earth Federation GAT model mobile suits. Clotho, Orga and Shani take a combat drug known as Gamma Glypheptin. This drug enhances their stamina as well as reaction time while in combat. The drug has a side effect that causes severe withdrawl symptoms in the nervous system. As the pilot of the GAT-X370 Raider Gundam, Clotho is a great annoyance to both Kira Yamato and Athrun Zala during the final stages of the war.