Mito Uzumaki was a kunoichi who originated from Uzushiogakure's Uzumaki clan and later married into Konohagakure's Senju clan. She was also the first jinchūriki of Kurama the Nine-Tailed Demon Fox. Manga Debut: Chapter #500 Anime Debut: Naruto Shippuuden Episode #247 (source: Narutopedia)