Rem is an ordinary woman in our world but, in the world of dreams, she becomes a dream warrior, defending humanity from the evils there. When dream demons reach the waking world, she fights them with the help of her pets which transform into a tiger and wolf.

Dream Hunter Rem was originally supposed to be a hentai OVA, but the first episode proved so popular that the following two episodes were released for the general market, with episode one being redone as a non-hentai "Special Version," with the sex scenes removed. The original, hentai episode one was never released on LaserDisc or DVD.