In the kingdom of Rimgarde, two mysterious giant robots begin a duel that erases nearly all human life before they disappear. Twelve years later, the young empress of Enastoria, Yuinshiel Asteria, works tirelessly to maintain both her authority and the support of her citizens. But the peace of Enastoria is threatened when survivors of Rimgarde arrive. Armed with giant robots called Regalia Gear, they look for Yuinshiel's adopted sister, Rena. The latter is forced to reveal herself as not just a Regalia Gear wielder, but a real "Regalia"—a human capable of transforming into a giant robot—and the culprit behind the fall of Rimgarde. Suddenly caught up in an international dispute, Yuinshiel must preserve the security of her country while also protecting Rena from those who wish to abuse her powers. However, by fighting for her sister, Yuinshiel risks triggering the same calamity that once destroyed Rimgarde. Amid such a precarious situation, the two girls push their bond to its limits as they fight not only for themselves but for the world's safety as well. [Written by MAL Rewrite]

Regalia: The Three Sacred Stars was released on Blu-ray and DVD in six volumes from November 2, 2016, to April 4, 2017. The English version was made available by Funimation as a set of the complete series on September 5, 2017. The Radio Regalia: Kaede Honda's Enastoria Imperial News Channel program featuring discussions of the series by the show's voice actors streamed on the Onsen internet radio station from September 22, 2016, to December 8, 2016. The program was made available on CD on January 25, 2017.