Following a 15-year long seclusion in a research facility, brothers Naoto and Naoya Kirihara finally escape after the psychic barrier separating them from the outside world collapses. Abandoned by their parents, who feared their supernatural powers, the siblings now strive for a normal life. However, the two are soon forced to use their talents to save lives as the "minus energy" begins to engulf the world and crimes involving psychic abilities gradually multiply. Learning to control their capabilities and using them for the sake of others will prove challenging, for Naoya is traumatized by his psychic abilities that allow him to read people's minds; while Naoto has hurt many close ones due to his unstable psychokinetic powers. With the help of the mysterious Shouko Futami, who can see into the future, the Kirihara brothers must find a way to foil the plans of an organization that seems to be linked to the harmful events related to gifted individuals. [Written by MAL Rewrite]

Night Head Genesis is an adaptation of the 1992 Japanese television drama Night Head. The series was released on DVD in five volumes by Media Blasters from October 28, 2008 to May 12, 2009.